| Pair Name | Gambogenic acid, Fluorouracil | ||
| Phytochemical Name | Gambogenic acid (PubChem CID: 10794070 ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Gambogenic acid, Fluorouracil | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Necroptosis | |||
| Gene Regulation | Up-regulation | Expression | AIFM1 | hsa9131 |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | CASP3 | hsa836 | |
| Up-regulation | Expression | CASP9 | hsa842 | |
| Up-regulation | Expression | CYCS | hsa54205 | |
| Up-regulation | Expression | PPID | hsa5481 | |
| Up-regulation | Expression | RIPK1 | hsa8737 | |
| In Vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
| Result | These mechanisms may be due to the toxicity of targeted toxin to mitochondria via the mitochondrial pathway. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergistic effects of 5-fluorouracil and gambogenic acid on A549 cells: activation of cell death caused by apoptotic and necroptotic mechanisms via the ROS-mitochondria pathway. Biol Pharm Bull. 2014;37(8):1259-68. doi: 10.1248/bpb.b13-00972. | Click |
